The Science

RejuvenatePlus™ Double Blind Trial in OA Dogs
Results of RejuvenatePlus™ Customer Survey

RejuvenatePlus™ Double Blind Trial in OA Dogs

Read the RejuvenatePlus™ Efficacy Study

Results of RejuvenatePlus™ Customer Survey

Prepared by Dr. Donald W. Miller
Associate Professor Dept. Pharmacology and Therapeutics, University of Manitoba
November, 2007

Survey Design

  • Carried out under the direction of Dr. Andrew Kliewer, DVM; Heartland Animal Hospital (Omaha, NE)
  • Enrollment target of 25 participants-only enrollment criteria being that dog has mobility/pain issues due to age or breed related joint and/or muscle problems
  • Respondents administered questionnaire following 10 day trial period on RejuvenatePlus™
  • Provided opportunity to enroll in 30-day clinical trial after completion of survey
  • Survey and clinical trial approximately 60% to completion

Profile of Survey Participants

  • Average age of dog was 13.5 yrs; participants ranged in age from 10-18 yrs
    88% surveyed had tried at least one other dietary supplement to treat decreased mobility and sore joints
  • 78% surveyed had tried prescription based medication for treating decreased mobility and sore joints

Reasons for Trying RejuvenatePlus™?

Reasons for Trying RejuvenatePlus™

User Experience with RejuvenatePlus™

  • Survey respondents asked to rate their experience with the product on a scale from 1-10, with:
    • 1=Strongly agree
    • 5=Agree
    • 10=Strongly disagree
  • Survey respondents indicate RejuvenatePlus™ produced improvements in dog’s health, energy, and mobility

I have seen noticeable differences in my dog’s health with RejuvenatePlus™

Differences in Dog’s Health

I have seen noticeable differences in my dog’s energy level with RejuvenatePlus™

Differences in Dog’s Energy Level

I have seen noticeable differences in my dog’s mobility with RejuvenatePlus™

Differences in Dog’s Mobility

Comparison of RejuvenatePlus™ to Other Supplements Used to Treat Mobility and Joint Problems

Comparison of Supplements

Comparison to Prescription Medications

Time Required for Observing Positive Treatment Response to RejuvenatePlus™

Time Required for Observing Positive Treatment

Dosing Frequency for RejuvenatePlus™

Dosing Frequency

Summary of Survey Results

  • 100% of respondents indicated observing improvements in energy level and/or mobility of their dog while on RejuvenatePlus™
  • 75% of respondents felt RejuvenatePlus™ performed better than other supplements taken for joint and mobility problems
  • Over 60% of respondents felt RejuvenatePlus™ performed better than prescription medication taken for joint and mobility problems
  • Over 97% of respondents reported seeing noticeable responses to RejuvenatePlus™ within 4-7 days

Blood Chemistry Table

When giving your dog any medication or dietary supplement, the dogs safety is paramount. As the makers of RejuvenatePlus, we share your same commitment to safety. The amino acid contained in our product has been used as a human dietary supplement for over 15 years, and its safety record is unblemished. However, to ensure the safety of RejuvenatePlus in dogs, we performed a clinical trial under the supervision of Dr. Andrew Kliewer, DVM. In his trial dogs were administered RejuvenatePlus for 30 days. Blood samples and clinical evaluations were performed on the dogs both prior to and immediately following the 30-day trial. The results of the blood analysis are shown in the table below. The blood tests show that RejuvenatePlus has no detrimental effects on blood chemistry, kidney or liver function.

Table 1: Blood Chemistry Results for 30-day RejuvenatePlus™ Trial in Dogs.
Blood Test Before Rejuvenate After Rejuvenate Normal Reference Range
Glucose (mg/dl) 92.4 + 5.0 84.6 + 3.3 70-120
BUN (mg/dl) 25.8 + 2.0 20.3 + 3.5 10-28
Blood creatinine (mg/dl) 1.6 + 0.2 1.3 + 0.1 0.5-1.50
ALT (IU/L) 77.2 + 15.6 76.6 + 16.6 <100
Bilirubin (mg/dl) 0.28 + 0.1 0.27 + 0.1 <0.6
Alkaline Phosphatase (U/L)** 236.4 + 153.9 213.1 + 110.9 <95
Cholesterol (mg/dl) 258.0 + 33.0 248.7 + 29.8 125-260
Calcium (mg/dl) 10.3 + 0.3 9.6 + 0.3 8.3-12.0
Phosphorus (mg/dl) 5.5 + 0.2 5.2 + 0.1 2.8-5.7
Sodium (mg/dl) 150.4 + 2.1 148.6 + 1.0 138-154
Potassium (mg/dl) 5.5 + 0.2 5.2 + 0.1 3.7-5.8
Chloride (mg/dl) 117.4 + 3.6 115.1 + 1.8 104-118
Serum protein (g/dl) 7.2 + 0.2 6.7 + 0.2 5.4-7.5
Serum albumin (g/dl) 3.2 + 0.1 2.9 + 0.1 2.5-3.9
CK total (U/L) 135.7 + 79.8 119.4 +11.7 10-200
Amylase (IU/L) 939.3 + 32.3 858.4 + 83.0 300-1750
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